<?xml version=“1.0” encoding=“UTF-8”?> <SubstanceSpecification xmlns=“hl7.org/fhir”>

<id value="example"/>
<!--  numberOfMoieties value="2"/>
<identifier>
   <system value="http://substanceidOID"/>
   <value value="POYFG4531Y (Artificial ID)"/>
</identifier>
<substanceType>
   <coding>
      <system value="http://substancetypeOID"/>
      <code value="Chemical"/>
   </coding>
</substanceType>
<moiety>
   <moietyRole>
      <coding>
         <system value="http://moietyroleOID"/>
         <code value="SaltMolecule"/>
      </coding>
   </moietyRole>
   <moietyId>
      <system value="http://moietyidOID"/>
      <value value="HJFGTE8954 (Artificial ID); [QTT17582CB (UNII)]"/>
   </moietyId>
   <moietyName value="Hydrochloric acid"/>
   <stereochemistry>
      <coding>
         <system value="http://stereochemistryOID"/>
         <code value="Achiral"/>
      </coding>
   </stereochemistry>
   <opticalActivity>
      <coding>
         <system value="http://opticalactivityOID"/>
         <code value="N/A"/>
      </coding>
   </opticalActivity>
   <molecularFormula value="HCl"/>
   <amount>
      <amountType>
         <coding>
            <system value="http://amounttypeOID"/>
            <code value="MoleRatiotoParent"/>
         </coding>
      </amountType>
      <average>
         <value value="1"/>
         <unit value="1"/>
      </average>
      <nonNumericValue value="Mole Ratio to Ponatinib"/>
   </amount>
</moiety>
<moiety>
   <moietyRole>
      <coding>
         <system value="http://moietyroleOID"/>
         <code value="Parentsubstance"/>
      </coding>
   </moietyRole>
   <moietyId>
      <system value="http://moietyidOID"/>
      <value value="PONG785632B (Artificial ID); [QTT17582CB (UNII)]"/>
   </moietyId>
   <moietyName value="Ponatinib"/>
   <stereochemistry>
      <coding>
         <system value="http://stereochemistryOID"/>
         <code value="Achiral"/>
      </coding>
   </stereochemistry>
   <opticalActivity>
      <coding>
         <system value="http://opticalactivityOID"/>
         <code value="N/A"/>
      </coding>
   </opticalActivity>
   <molecularFormula value="C29H27F3N6O"/>
   <amount>
      <amountType>
         <coding>
            <system value="http://amounttypeOID"/>
            <code value="MoleRatiotoAcid"/>
         </coding>
      </amountType>
      <average>
         <value value="1"/>
         <unit value="1"/>
      </average>
      <nonNumericValue value="Mol Ratio Ponatinib/ Ponatinib hydrochloride (1:1)"/>
   </amount>
</moiety>
<referenceInformation>
   <substanceClassification>
      <domain>
         <coding>
            <system value="http://domainOID"/>
            <code value="HumanPharmaceutical"/>
         </coding>
      </domain>
      <substanceClassificationCode value="L01XE24"/>
      <substanceClassificationType value="Ponatinib"/>
      <referenceSource>
         <publicDomain value="true"/>
         <referenceSourceType>
            <coding>
               <system value="http://referencesourcetypeOID"/>
               <code value="WHOCollaboratingCentreforDrugStatisticsmethodology(WHOCC)"/>
            </coding>
         </referenceSourceType>
         <referenceSourceClass>
            <coding>
               <system value="http://referencesourceclassOID"/>
               <code value="Web"/>
            </coding>
         </referenceSourceClass>
         <referenceSourceCitation value="http://www.whocc.no/atc_ddd_index/?code=L01XE24 "/>
      </referenceSource>
   </substanceClassification>
   <substanceRelationship>
      <relatedSubstanceId>
         <system value="http://relatedsubstanceidOID"/>
         <value value="GHF26754YQ (Artificial ID), [4340891KFS (UNII)]"/>
      </relatedSubstanceId>
      <relatedSubstanceName value="Ponatinib"/>
      <relationship>
         <coding>
            <system value="http://relationshipOID"/>
            <code value="Parentsubstancetosalt"/>
         </coding>
      </relationship>
      <relationshipType>
         <coding>
            <system value="http://relationshiptypeOID"/>
            <code value="Ionic"/>
         </coding>
      </relationshipType>
      <isDefining value="true"/>
      <amount>
         <amountType>
            <coding>
               <system value="http://amounttypeOID"/>
               <code value="Weightpercenttosalt"/>
            </coding>
         </amountType>
         <average>
            <value value="93.6"/>
            <unit value="1"/>
         </average>
         <unit>
            <coding>
               <system value="http://unitOID"/>
               <code value="Weightpercent"/>
            </coding>
         </unit>
         <nonNumericValue value="Equivalent factor: 0.936"/>
      </amount>
   </substanceRelationship>
</referenceInformation>
<referenceSource>
   <publicDomain value="false"/>
   <referenceSourceType>
      <coding>
         <system value="http://referencesourcetypeOID"/>
         <code value="MarketingAuthorisationApplication"/>
      </coding>
   </referenceSourceType>
   <referenceSourceClass>
      <coding>
         <system value="http://referencesourceclassOID"/>
         <code value="Regulatorysubmission"/>
      </coding>
   </referenceSourceClass>
   <referenceSourceId value="33333 (Artificial ID)"/>
   <referenceSourceDocument>
      <document>
         <contentType value="text/plain"/>
         <data value="U3lteXggICAwNjA5MTQyMjExMkQgMSAgIDEuMDAwMDAgICAgIDAuMDAwMDAgICAgIDAgXG4gNDAgNDMgIDAgICAgIDAgIDAgICAgICAgICAgICA5OTkgVjIwMDBcbiAgIC0yLjIzNDAgICAtMC4xNjYxICAgIDAuMDAwMCBOICAgMCAgMCAgMCAgMCAgMCAgMCAgICAgICAgICAgMCAgMCAgMA=="/>
      </document>
      <referenceSourceDocumentType>
         <coding>
            <system value="http://referencesourcedocumenttypeOID"/>
            <code value="Textfile"/>
         </coding>
      </referenceSourceDocumentType>
   </referenceSourceDocument>
</referenceSource>
<structure>
   <stereochemistry>
      <coding>
         <system value="http://stereochemistryOID"/>
         <code value="Achiral"/>
      </coding>
   </stereochemistry>
   <opticalActivity>
      <coding>
         <system value="http://opticalactivityOID"/>
         <code value="N/A"/>
      </coding>
   </opticalActivity>
   <molecularFormula value="C29H28F3ClN6O"/>
   <molecularFormulaByMoiety value="C29H27F3N6O.HCl"/>
   <molecularWeight>
      <molecularWeightMethod>
         <coding>
            <system value="http://molecularweightmethodOID"/>
            <code value="Calculated"/>
         </coding>
      </molecularWeightMethod>
      <molecularWeightType>
         <coding>
            <system value="http://molecularweighttypeOID"/>
            <code value="Numberaverage"/>
         </coding>
      </molecularWeightType>
      <amount>
         <amountType>
            <coding>
               <system value="http://amounttypeOID"/>
               <code value="Exact"/>
            </coding>
         </amountType>
         <average>
            <value value="569.02"/>
            <unit value="1"/>
         </average>
         <unit>
            <coding>
               <system value="http://unitOID"/>
               <code value="g/mol"/>
            </coding>
         </unit>
      </amount>
   </molecularWeight>
   <referenceSource>
      <publicDomain value="true"/>
      <referenceSourceType>
         <coding>
            <system value="http://referencesourcetypeOID"/>
            <code value="ChemIDplus"/>
         </coding>
      </referenceSourceType>
      <referenceSourceClass>
         <coding>
            <system value="http://referencesourceclassOID"/>
            <code value="PublicDatabase"/>
         </coding>
      </referenceSourceClass>
      <referenceSourceCitation value="http://chem.sis.nlm.nih.gov/chemidplus/unii/96R6PU3D8J "/>
   </referenceSource>
   <structuralRepresentation>
      <type>
         <coding>
            <system value="http://structuralrepresentationtypeOID"/>
            <code value="Full"/>
         </coding>
      </type>
      <representation value="Figure B.40"/>
   </structuralRepresentation>
   <structuralRepresentation>
      <type>
         <coding>
            <system value="http://structuralrepresentationtypeOID"/>
            <code value="InChI"/>
         </coding>
      </type>
      <representation value="InChI=1S/C29H27F3N6O.ClH/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37;/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);1H"/>
   </structuralRepresentation>
   <structuralRepresentation>
      <type>
         <coding>
            <system value="http://structuralrepresentationtypeOID"/>
            <code value="SMILES"/>
         </coding>
      </type>
      <representation value="Cc1ccc(cc1C#Cc2cnc3n2nccc3)C(=O)Nc4ccc(c(c4)C(F)(F)F)CN5CCN(CC5)C.Cl"/>
   </structuralRepresentation>
   <structuralRepresentation>
      <type>
         <coding>
            <system value="http://structuralrepresentationtypeOID"/>
            <code value="MOL"/>
         </coding>
      </type>
      <attachment>
         <contentType value="text/plain"/>
         <data value="U3lteXggICAwNjA5MTQyMjExMkQgMSAgIDEuMDAwMDAgICAgIDAuMDAwMDAgICAgIDAgXG4gNDAgNDMgIDAgICAgIDAgIDAgICAgICAgICAgICA5OTkgVjIwMDBcbiAgIC0yLjIzNDAgICAtMC4xNjYxICAgIDAuMDAwMCBOICAgMCAgMCAgMCAgMCAgMCAgMCAgICAgICAgICAgMCAgMCAgMA=="/>
      </attachment>
   </structuralRepresentation>
</structure>
<substanceCode>
   <code value="1114544-31-8"/>
   <codeSystemStatus>
      <coding>
         <system value="http://1.1.149"/>
         <code value="Active"/>
      </coding>
   </codeSystemStatus>
</substanceCode>
<substanceCode>
   <code value="96R6PU3D8J"/>
   <codeSystemStatus>
      <coding>
         <system value="http://1.1.150"/>
         <code value="Active"/>
      </coding>
   </codeSystemStatus>
</substanceCode>
<substanceName>
   <substanceName value="Ponatinib hydrochloride"/>
   <substanceNameType>
      <coding>
         <system value="http://substancenametypeOID"/>
         <code value="Official"/>
      </coding>
   </substanceNameType>
   <language>
      <coding>
         <system value="http://languageOID"/>
         <code value="en"/>
      </coding>
   </language>
   <substanceNameDomain>
      <coding>
         <system value="http://substancenamedomainOID"/>
         <code value="Drug"/>
      </coding>
   </substanceNameDomain>
   <jurisdiction>
      <coding>
         <system value="http://jurisdictionOID"/>
         <code value="EU,US"/>
      </coding>
   </jurisdiction>
   <officialName>
      <officialNameType>
         <coding>
            <system value="http://officialnametypeOID"/>
            <code value="USAN"/>
         </coding>
      </officialNameType>
      <officialNameStatus>
         <coding>
            <system value="http://officialnamestatusOID"/>
            <code value="Current"/>
         </coding>
      </officialNameStatus>
   </officialName>
   <referenceSource>
      <publicDomain value="true"/>
      <referenceSourceType>
         <coding>
            <system value="http://referencesourcetypeOID"/>
            <code value="Martindale"/>
         </coding>
      </referenceSourceType>
      <referenceSourceClass>
         <coding>
            <system value="http://referencesourceclassOID"/>
            <code value="Officialnamesource"/>
         </coding>
      </referenceSourceClass>
      <referenceSourceCitation value="Martindale The complete drug reference"/>
      <referenceSourceUrl value="https://www.medicinescomplete.com/mc/martindale/current/ms-28485-s.htm?q=Ponatinib%20hydrochloride&amp;t=search&amp;ss=text&amp;tot=12&amp;p=1#_hit"/>
      <referenceSourceDocument>
         <publicDomain value="true"/>
         <referenceSourceDocumentType>
            <coding>
               <system value="http://referencesourcedocumenttypeOID"/>
               <code value="Journalarticle"/>
            </coding>
         </referenceSourceDocumentType>
      </referenceSourceDocument>
   </referenceSource>
</substanceName>
<substanceName>
   <substanceName value="3-(2-(Imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide monohydrochloride"/>
   <substanceNameType>
      <coding>
         <system value="http://substancenametypeOID"/>
         <code value="Systematic"/>
      </coding>
   </substanceNameType>
   <language>
      <coding>
         <system value="http://languageOID"/>
         <code value="en"/>
      </coding>
   </language>
   <referenceSource>
      <publicDomain value="true"/>
      <referenceSourceType>
         <coding>
            <system value="http://referencesourcetypeOID"/>
            <code value="ChemIDplus"/>
         </coding>
      </referenceSourceType>
      <referenceSourceClass>
         <coding>
            <system value="http://referencesourceclassOID"/>
            <code value="PublicDatabase"/>
         </coding>
      </referenceSourceClass>
      <referenceSourceCitation value="http://chem.sis.nlm.nih.gov/chemidplus/unii/96R6PU3D8J "/>
   </referenceSource>
</substanceName>
<substanceName>
   <substanceName value="Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-,hydrochloride (1:1)"/>
   <substanceNameType>
      <coding>
         <system value="http://substancenametypeOID"/>
         <code value="OtherName"/>
      </coding>
   </substanceNameType>
   <language>
      <coding>
         <system value="http://languageOID"/>
         <code value="en"/>
      </coding>
   </language>
   <referenceSource>
      <publicDomain value="true"/>
      <referenceSourceType>
         <coding>
            <system value="http://referencesourcetypeOID"/>
            <code value="CAS"/>
         </coding>
      </referenceSourceType>
      <referenceSourceClass>
         <coding>
            <system value="http://referencesourceclassOID"/>
            <code value="Othernamesource"/>
         </coding>
      </referenceSourceClass>
      <referenceSourceCitation value="CAS Registry Name"/>
   </referenceSource>
</substanceName>
<substanceName>
   <substanceName value="XYWZ123"/>
   <substanceNameType>
      <coding>
         <system value="http://substancenametypeOID"/>
         <code value="CompanyCode"/>
      </coding>
   </substanceNameType>
   <language>
      <coding>
         <system value="http://languageOID"/>
         <code value="en"/>
      </coding>
   </language>
   <referenceSource>
      <publicDomain value="false"/>
      <referenceSourceType>
         <coding>
            <system value="http://referencesourcetypeOID"/>
            <code value="MarketingAuthorisationApplication"/>
         </coding>
      </referenceSourceType>
      <referenceSourceClass>
         <coding>
            <system value="http://referencesourceclassOID"/>
            <code value="Regulatorysubmission"/>
         </coding>
      </referenceSourceClass>
      <referenceSourceId value="CBG345267C (Artificial ID)"/>
   </referenceSource>
</substanceName  -->

<meta>

  <security>
    <system value="http://terminology.hl7.org/CodeSystem/v3-ActReason"/>
    <code value="HTEST"/>
    <display value="test health data"/>
  </security>
</meta>
</SubstanceSpecification>