<?xml version=“1.0” encoding=“UTF-8”?><Observation xmlns=“hl7.org/fhir”>

<id value="genetics-example1-somatic"/>
<text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative with Details</b></p><p><b>id</b>: genetics-example1-somatic</p><p><b>contained</b>: </p><p><b>status</b>: final</p><p><b>code</b>: Genetic analysis master panel ­Blood or Tissue by Molecular genetics method <span>(Details : {LOINC code &#39;55233-1&#39; = &#39;Genetic analysis master panel - Blood or Tissue by Molecular genetics method&#39;, given as &#39;Genetic analysis master panel ­Blood or Tissue by Molecular genetics method&#39;})</span></p><p><b>subject</b>: <a>Molecular Lab Patient ID: HOSP-23456</a></p><p><b>performer</b>: <a>Molecular Diagnostic Laboratory</a></p><p><b>interpretation</b>: positive <span>(Details : {http://hl7.org/fhir/v2/0078 code &#39;POS&#39; = &#39;Positive)</span></p><p><b>comments</b>: The EGFR p.L858R mutation has been associated with response to anti-EGFR therapy</p><p><b>specimen</b>: <a>Molecular Specimen ID: MLD45-Z4-1234</a></p></div></text><contained>
    <Condition>
        <id value="c1"/>
        <patient>
            <reference value="Patient/p1"/>
        </patient>
        <code>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="254626006"/>
            </coding>
            <text value="Adenocarcinoma of lung "/>
        </code>
        <category>
            <coding>
                <system value="http://hl7.org/fhir/condition-category"/>
                <code value="finding"/>
                <display value="Finding"/>
            </coding>
        </category>
        <verificationStatus value="provisional"/>
    </Condition>
</contained>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomeBuild">
    <valueString value="GRCh 37"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsChromosome">
    <valueCodeableConcept>
        <coding>
            <system value="http://www.ncbi.nlm.nih.gov/gene"/>
            <code value="NC_000007"/>
        </coding>
        <text value="Homo sapiens chromosome 7"/>
    </valueCodeableConcept>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomicStart">
    <valueInteger value="55259515"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomicStop">
    <valueInteger value="55259516"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsSpecies">
    <valueCodeableConcept>
        <coding>
            <system value="http://snomed.info/sct"/>
            <code value="337915000"/>
        </coding>
        <text value="Homo sapiens"/>
    </valueCodeableConcept>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsCIGAR">
    <valueString value="1M"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsAssessedCondition">
    <valueReference>
        <reference value="#c1"/>
    </valueReference>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsReferenceAllele">
    <valueString value="T"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsObservedAllele">
    <valueString value="G"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsGene">
    <valueCodeableConcept>
        <coding>
            <system value="http://www.genenames.org"/>
            <code value="3236"/>
            <display value="EGFR"/>
        </coding>
    </valueCodeableConcept>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsTranscriptReferenceSequenceId">
    <valueCodeableConcept>
        <coding>
            <system value="http://www.ensembl.org"/>
            <code value="ENSESTT00000085772.1"/>
        </coding>
    </valueCodeableConcept>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsDNASequenceVariation">
    <valueString value="c.2573T&gt;G"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsDNASequenceVariationType">
    <valueCodeableConcept>
        <coding>
            <system value="http://loinc.org"/>
            <code value="LA6690-7"/>
            <display value="Substitution"/>
        </coding>
    </valueCodeableConcept>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsAminoAcidChange">
    <valueString value="p.Leu858Arg"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsAlleleName">
    <valueString value="p.L858R"/>
</extension>
<extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomicSourceClass">
    <valueCodeableConcept>
        <coding>
            <system value="http://loinc.org"/>
            <code value="LA6684-0"/>
            <display value="Somatic"/>
        </coding>
    </valueCodeableConcept>
</extension>

<status value="final"/>
<code>
    <coding>
        <system value="http://loinc.org"/>
        <code value="55233-1"/>
        <display value="Genetic analysis master panel ­Blood or Tissue by Molecular genetics method"/>
    </coding>
</code>
<subject>
    <reference value="Patient/genetics-example1-somatic"/>
    <display value="Molecular Lab Patient ID: HOSP-23456"/>
</subject>
<performer>
    <reference value="Practitioner/genetics-example1-somatic"/>
    <display value="Molecular Diagnostic Laboratory"/>
</performer>
<interpretation>
    <coding>
        <system value="http://hl7.org/fhir/v2/0078"/>
        <code value="POS"/>
    </coding>
    <text value="positive"/>
</interpretation>
<comments value="The EGFR p.L858R mutation has been associated with response to anti-EGFR therapy"/>
<specimen>
    <reference value="Specimen/genetics-example1-somatic"/>
    <display value="Molecular Specimen ID: MLD45-Z4-1234"/>
</specimen>

</Observation>