quadratic {MCPMod} | R Documentation |
The model function for the quadratic model is defined as
f(d,\theta)=E_0+\beta_1d+\beta_2d^2
quadratic(dose, e0, b1, b2)
dose |
Dose variable |
e0 |
Placebo effect |
b1 |
beta1 parameter |
b2 |
beta2 parameter (controls, whether model is convex or concave) |
This model is intended to capture a possible non-monotonic dose-response relationship.
Response value
Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146–171
logistic
, sigEmax
,
linlog
, linear
, exponential
,
emax
, betaMod