pk.calc.auciv {PKNCA}R Documentation

Calculate AUC for intravenous dosing

Description

Calculate AUC for intravenous dosing

Usage

pk.calc.auciv(conc, time, c0, auc, ..., check = TRUE)

pk.calc.auciv_pbext(auc, auciv)

Arguments

conc

Concentration measured

time

Time of concentration measurement (must be monotonically increasing and the same length as the concentration data)

c0

The concentration at time 0, typically calculated using pk.calc.c0()

auc

The AUC calculated using conc and time without c0 (it may be calculated using any method)

...

For functions other than pk.calc.auxc, these values are passed to pk.calc.auxc

check

Run check.conc.time, clean.conc.blq, and clean.conc.na?

auciv

The AUC calculated using c0

Details

The AUC for intravenous (IV) dosing extrapolates the AUC back from the first measurement to time 0 using c0 and the AUC calculated by another method (for example the auclast).

The calculation method takes the following steps:

The calculation for back-extrapolation is 100*(1 - auc/auciv).

Value

pk.calc.auciv: The AUC calculated using c0

pk.calc.auciv_pctbackextrap: The AUC percent back-extrapolated

Functions


[Package PKNCA version 0.10.2 Index]