doseChoice {dfped} | R Documentation |
Algorithm giving the next dose which is the safe most successful dose (sMSD).
doseChoice(probaTox, probaEff, p, targetTox, givenDose)
probaTox |
The probability of toxicity estimated with STAN model. |
probaEff |
The probability of efficacy estimated with STAN model. |
p |
The probability of success. |
targetTox |
The target of toxicity. |
givenDose |
The vector of doses given to patients so far. |
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
r <- 0.10
q <- 0.17
p <- 0.9
targetTox <- 0.6
givenDose <- 2
newDose <- doseChoice(r, q, p, targetTox, givenDose)
newDose