newton.raphson {DTAT} | R Documentation |
This higher-order ('factory') function produces a simple dose titration algorithm for neutrophil-guided chemotherapy dosing.
newton.raphson(dose1, omega, slope1, slopeU)
dose1 |
The starting dose for titration |
omega |
A relaxation parameter used to moderate dose increments |
slope1 |
Dose-response slope assumed prior to 2nd measured neutrophil nadir |
slopeU |
Upper bound imposed on slope estimates |
This function manifests the core concept of Dose Titration Algorithm Tuning by delivering an objectively realized 'DTA'. It therefore enables a variety of DTAs to be implemented and compared.
A dose titration function that advises dose for next cycle of chemotherapy.
David C. Norris