lac_operon_net {pastboon} | R Documentation |
The lactose operon (lac operon) Boolean network as proposed by Veliz-Cuba and Stigler.
data(lac_operon_net)
The data consists of an object lac_operon_net
of the class BooleanNetwork
(from the BoolNet
package), describing the lac operon gene regulatory network with 10 genes and 3 inputs. The three inputs collectively indicate the concentration of glucose and lactose. Based on the synchronous update scheme, when extracellular glucose is available, the lac operon is OFF (having one steady-state attractor where all genes are OFF). Otherwise, depending on the extracellular lactose concentration, the operon will be OFF, bistable (having two attractors), or ON (all genes are ON).
Veliz-Cuba, A., & Stigler, B. (2011). Boolean models can explain bistability in the lac operon. Journal of computational biology, 18(6), 783-794.
# load the network
data(lac_operon_net)
# the network is stored in a variable called 'lac_operon_net'
print(lac_operon_net)