EmpiricalCalibration-package {EmpiricalCalibration} | R Documentation |
Routines for performing empirical calibration of observational study estimates. By using a set of negative control hypotheses we can estimate the empirical null distribution of a particular observational study setup. This empirical null distribution can be used to compute a calibrated p-value, which reflects the probability of observing an estimated effect size when the null hypothesis is true taking both random and systematic error into account. A similar approach can be used to calibrate confidence intervals, using both negative and positive controls. For more details, see Schuemie et al. (2013) doi:10.1002/sim.5925 and Schuemie et al. (2018) doi:10.1073/pnas.1708282114.
Maintainer: Martijn Schuemie schuemie@ohdsi.org (ORCID)
Authors:
Marc Suchard (ORCID)
Useful links:
Report bugs at https://github.com/OHDSI/EmpiricalCalibration/issues