pgo_binary {drugdevelopR} | R Documentation |
Probability to go to phase III for multiarm programs with binary distributed outcomes
Description
Given our parameters this function calculates the probability to go to phase III after the second phase was conducted. The considered strategies are as follows:
-
Strategy: Only best promising treatment goes to phase III
Usage
pgo_binary(RRgo, n2, p0, p11, p12, strategy, case)
Arguments
RRgo |
threshold value for the go/no-go decision rule |
n2 |
total sample size for phase II; must be even number |
p0 |
assumed true rate of control group |
p11 |
assumed true rate of treatment group |
p12 |
assumed true rate of treatment group |
strategy |
choose Strategy: 1 ("only best promising"), 2 ("all promising") |
case |
different cases: 1 ("nogo"), 21 (treatment 1 is promising, treatment 2 is not), 22 (treatment 2 is promising, treatment 1 is not), 31 (both treatments are promising, treatment 1 is better), 32 (both treatments are promising, treatment 2 is better) |
Value
The function pgo_binary() returns the probability to go to phase III.
Examples
res <- pgo_binary(RRgo = 0.8 ,n2 = 50 ,p0 = 0.6, p11 = 0.3, p12 = 0.5,strategy = 2, case = 31)