fit_powerest {PoweREST} | R Documentation |
Fit the power surface
Description
This function loads the power values with corresponding avg_log2FC and avg_PCT derived from bootstrap sampling and utilizes the scam package to fit two dimensional smoothing splines under monotone constraints: 1.positive relationship between power and avg_log2FC; 2.positive relationship between power and avg_PCT. The values of avg_log2FC and avg_PCT can be either from the averages of the bootstrap samples or from the original spatial transcriptomics data.
Usage
fit_powerest(power,avg_log2FC,avg_PCT,filter_zero=TRUE)
Arguments
power |
The raw power values. |
avg_log2FC |
The corresponding log2FC values. |
avg_PCT |
The corresponding PCT values. |
filter_zero |
Whether the user would like to filter to remove the power values being 0, default=TRUE. |
Value
A 'scam' object is the result of scam function. More information about the content of a 'scam' object can be found at the document of R package scam.
Author(s)
Lan Shui lshui@mdanderson.org
Examples
data(result_example)
b<-fit_powerest(result_example$power,result_example$avg_logFC,result_example$avg_PCT)