.distribute_freqs {GeRnika} | R Documentation |
Distribute frequencies among clone and its children clones
Description
This function distributes frequencies among the clones in a multifurcation of a phylogenetic tree. It uses a Dirichlet distribution to generate random proportions for a clone and its children, and then normalizes the children's proportions to the parent's proportion.
This is an internal function used by calc_clone_proportions
.
Usage
.distribute_freqs(B, clone_idx, clone_proportions, selection)
Arguments
B |
A matrix representing the mutation relationships between the nodes in the phylogenetic tree (B matrix). |
clone_idx |
An integer representing the index of the clone whose own proportion and its children's proportions are going to be updated. |
clone_proportions |
A numeric vector representing the proportions of each clone in the phylogenetic tree. |
selection |
A character string representing the evolutionary mode the tumor follows. This should be either "positive" or "neutral". |
Value
A numeric vector representing the updated proportions of each clone in the phylogenetic tree.