grantham-package {grantham}R Documentation

grantham: Calculate the Grantham Distance

Description

A minimal set of routines to calculate the Grantham distance doi:10.1126/science.185.4154.862. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

Author(s)

Maintainer: Ramiro Magno rmagno@pattern.institute (ORCID)

Authors:

Other contributors:

See Also

Useful links:


[Package grantham version 0.1.2 Index]