NMsim_NWPRI {NMsim} | R Documentation |
Simulate with parameter variability using the NONMEM NWPRI subroutine
Description
Modify control stream for simulation with uncertainty using inverse-Wishart distribution for OMEGA and SIGMA parameters
This function does not run any simulations. To simulate, using this method, see 'NMsim()'. See examples.
Usage
NMsim_NWPRI(file.sim, file.mod, data.sim, PLEV = 0.999)
Arguments
file.sim |
The path to the control stream to be edited. This function overwrites the contents of the file pointed to by file.sim. |
file.mod |
Path to the path to the original input control stream provided as 'file.mod' to 'NMsim()'. |
data.sim |
Included for compatibility with 'NMsim()'. Not used. |
PLEV |
Used in |
Details
Simulate with parameter uncertainty. THETA parameters are sampled from a multivariate normal distribution while OMEGA and SIGMA are simulated from the inverse-Wishart distribution. Correlations of OMEGA and SIGMA parameters will only be applied within modeled "blocks".
Author(s)
Brian Reilly, Philip Delff
References
See Also
NMsim_VarCov
Examples
## Not run:
simres <- NMsim(file.path,method.sim=NMsim_WPRI,typical=TRUE,subproblems=500)
## End(Not run)