NPguided {R4HCR} | R Documentation |
NP Guided Monitoring of Heart Failure.
Description
Data from a meta-analysis of natriuretic peptide-guided (NP-guided) treatment for heart failure.
Usage
NPguided
Format
A data frame with 18 observations on the following 7 variables.
studyid
Name and year of study.
year
Year of publication.
eventsnp
Number of events (all-cause mortality) in NP-guided monitoring group.
totalnp
Total number of participants in NP-guided monitoring group.
eventscntrl
Number of events (all-cause mortality) with treatment guided by clinical assessment alone.
totalcntrl
Total number of participants with treatment guided by clinical assessment alone.
comparator
Indicator for type of comparator arm in study (
0
= usual care,1
= clinical assessment).
Details
Natriuretic peptides (NP) are released by the myocardium in response to pressure or fluid overload and are raised in patients with heart failure (HF). NP is a collective term for N-terminal pro-B-type natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP). Studies compared NP-guided treatment to treatment guided by clinical assessment alone. These data are from a study that aimed to determine whether NP-guided treatment of patients with HF reduces all-cause mortality, amongst other outcomes.
References
McLellan J, Bankhead CR, Oke JL, Hobbs FDR, Taylor CJ, Perera R. Natriuretic peptide-guided treatment for heart failure: a systematic review and meta-analysis. BMJ Evid Based Med. 2020 Feb;25(1):33-37. doi: 10.1136/bmjebm-2019-111208. Epub 2019 Jul 20. PMID: 31326896; PMCID: PMC7029248.
Examples
require(meta)
data(NPguided, package = "R4HCR")
metabin(
sm = "RR",
method = "MH",
event.e = eventsnp,
n.e = totalnp,
event.c = eventscntrl,
n.c = totalcntrl,
studlab = studyid,
data = NPguided)