BeeGUTS-package {BeeGUTS}R Documentation

'BeeGUTS' package; a package to perform GUTS modelling for Bee experiments.

Description

Provide tools to analyse the survival toxicity tests performed for bee species. It can be used to fit a Toxicokinetic-Toxicodynamic (TKTD) model adapted for bee standard studies (acute oral, acute contact, and chronic oral studies). The TKTD model used is the General Unified Threshold model of Survival (GUTS).

The package follows the concept and assumptions presented in Baas et al. (2022)

References

Baas, J., Goussen, B., Taenzler, V., Roeben, V., Miles, M., Preuss, T.G., van den Berg, S. and Roessink, I. (2024), Comparing Sensitivity of Different Bee Species to Pesticides: A TKTD modeling approach. Environ Toxicol Chem, 43: 1431-1441. doi:10.1002/etc.5871

Baas, J., Goussen, B., Miles, M., Preuss, T.G., Roessing, I. (2022). BeeGUTS—A Toxicokinetic–Toxicodynamic Model for the Interpretation and Integration of Acute and Chronic Honey Bee Tests. doi:10.1002/etc.5423

Jager, T., Albert, C., Preuss, T.G. and Ashauer, R. (2011). General Unified Threshold model of Survival - a toxicokinetic-toxicodynamic framework for ecotoxicology. doi:10.1021/es103092a

Jager, T. and Ashauer, R. (2018). Modelling survival under chemical stress. A comprehensive guide to the GUTS framework. Version 1.0 https://leanpub.com/guts_book

EFSA PPR Scientific Opinion (2018). Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. https://www.efsa.europa.eu/en/efsajournal/pub/5377

EFSA (European Food Safety Authority), Adriaanse P, Arce A, Focks A, Ingels B, Jölli D, Lambin S, Rundlöf M, Süßenbach D, Del Aguila M, Ercolano V, Ferilli F, Ippolito A, Szentes Cs, Neri FM, Padovani L, Rortais A, Wassenberg J and Auteri D, (2023). Revised guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees). EFSA Journal doi:10.2903/j.efsa.2023.7989

Stan Development Team (2020). RStan: the R interface to Stan. R package version 2.21.2. https://mc-stan.org


[Package BeeGUTS version 1.3.0 Index]