%global __brp_check_rpaths %{nil} %global __requires_exclude ^libmpi %global packname escalation %global packver 0.1.10 %global rlibdir /usr/local/lib/R/library Name: R-CRAN-%{packname} Version: 0.1.10 Release: 1%{?dist}%{?buildtag} Summary: A Modular Approach to Dose-Finding Clinical Trials License: GPL (>= 3) URL: https://cran.r-project.org/package=%{packname} Source0: %{url}&version=%{packver}#/%{packname}_%{packver}.tar.gz BuildRequires: R-devel Requires: R-core BuildArch: noarch BuildRequires: R-CRAN-tidyr >= 1.0 BuildRequires: R-CRAN-trialr >= 0.1.5 BuildRequires: R-CRAN-magrittr BuildRequires: R-CRAN-dplyr BuildRequires: R-CRAN-tidyselect BuildRequires: R-CRAN-stringr BuildRequires: R-CRAN-purrr BuildRequires: R-CRAN-tibble BuildRequires: R-CRAN-ggplot2 BuildRequires: R-CRAN-gtools BuildRequires: R-CRAN-dfcrm BuildRequires: R-CRAN-BOIN BuildRequires: R-CRAN-DiagrammeR BuildRequires: R-CRAN-RColorBrewer BuildRequires: R-CRAN-viridis BuildRequires: R-CRAN-binom BuildRequires: R-CRAN-R6 BuildRequires: R-CRAN-mvtnorm BuildRequires: R-CRAN-testthat Requires: R-CRAN-tidyr >= 1.0 Requires: R-CRAN-trialr >= 0.1.5 Requires: R-CRAN-magrittr Requires: R-CRAN-dplyr Requires: R-CRAN-tidyselect Requires: R-CRAN-stringr Requires: R-CRAN-purrr Requires: R-CRAN-tibble Requires: R-CRAN-ggplot2 Requires: R-CRAN-gtools Requires: R-CRAN-dfcrm Requires: R-CRAN-BOIN Requires: R-CRAN-DiagrammeR Requires: R-CRAN-RColorBrewer Requires: R-CRAN-viridis Requires: R-CRAN-binom Requires: R-CRAN-R6 Requires: R-CRAN-mvtnorm Requires: R-CRAN-testthat %description Methods for working with dose-finding clinical trials. We provide implementations of many dose-finding clinical trial designs, including the continual reassessment method (CRM) by O'Quigley et al. (1990) , the toxicity probability interval (TPI) design by Ji et al. (2007) , the modified TPI (mTPI) design by Ji et al. (2010) , the Bayesian optimal interval design (BOIN) by Liu & Yuan (2015) , EffTox by Thall & Cook (2004) ; the design of Wages & Tait (2015) , and the 3+3 described by Korn et al. (1994) . All designs are implemented with a common interface. We also offer optional additional classes to tailor the behaviour of all designs, including avoiding skipping doses, stopping after n patients have been treated at the recommended dose, stopping when a toxicity condition is met, or demanding that n patients are treated before stopping is allowed. By daisy-chaining together these classes using the pipe operator from 'magrittr', it is simple to tailor the behaviour of a dose-finding design so it behaves how the trialist wants. Having provided a flexible interface for specifying designs, we then provide functions to run simulations and calculate dose-paths for future cohorts of patients. %prep %setup -q -c -n %{packname} # fix end of executable files find -type f -executable -exec grep -Iq . {} \; -exec sed -i -e '$a\' {} \; # prevent binary stripping [ -d %{packname}/src ] && find %{packname}/src -type f -exec \ sed -i 's@/usr/bin/strip@/usr/bin/true@g' {} \; || true [ -d %{packname}/src ] && find %{packname}/src/Make* -type f -exec \ sed -i 's@-g0@@g' {} \; || true # don't allow local prefix in executable scripts find -type f -executable -exec sed -Ei 's@#!( )*/usr/local/bin@#!/usr/bin@g' {} \; %build %install mkdir -p %{buildroot}%{rlibdir} %{_bindir}/R CMD INSTALL -l %{buildroot}%{rlibdir} %{packname} test -d %{packname}/src && (cd %{packname}/src; rm -f *.o *.so) rm -f %{buildroot}%{rlibdir}/R.css # remove buildroot from installed files find %{buildroot}%{rlibdir} -type f -exec sed -i "s@%{buildroot}@@g" {} \; %files %{rlibdir}/%{packname}