isPopulation |
Is this a population model TRUE or individual model FALSE ?
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parameterization |
Type of parameterization. Options are "Clearance" , "Micro" ,
"Macro" , or "Macro1" .
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absorption |
Type of absorption. Options are "Intravenous" , "FirstOrder" ,
"Gamma" , "InverseGaussian" , "Weibull" .
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numCompartments |
Value of either 1 , 2 , or 3 .
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isClosedForm |
Set to TRUE to convert model from a differential equation to close form.
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isTlag |
Set to TRUE to add a lag time parameter to the model.
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hasEliminationComp |
Set to TRUE to add an elimination compartment to the model.
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isFractionExcreted |
Set to TRUE if elimination compartment (hasEliminationComp = TRUE )
contains a fraction excreted parameter.
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isSaturating |
Set to TRUE to use Michaelis-Menten kinetics for elimination.
Only applicable to models with paramteterization = "Clearance"
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infusionAllowed |
Set to TRUE if infusions allowed.
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isDuration |
Set to TRUE if infusions use duration instead of rate
(must also set infusionAllowed = TRUE ).
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isStdevFrozen |
Set to TRUE to freeze value of standard deviation of residual error variable.
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data |
Input dataset
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columnMap |
If TRUE (default) column mapping arguments are required.
Set to FALSE to manually map columns after defining model using colMapping .
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modelName |
Model name for subdirectory created for model output in current working directory.
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workingDir |
Working directory to run the model. Current working directory will be used
if workingDir not specified.
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... |
Arguments passed on to pkmodel_MappingParameters
ID Column mapping argument for input dataset column(s) that identify
individual data profiles. Only applicable to population models isPopulation = TRUE .
Time Column mapping argument that represents the input dataset column
for the relative time used in a study and only applicable to time-based models.
A1 Column mapping argument that represents the input dataset column
for the amount of drug administered. Only applicable to the following types of models:
Models with absorption = "Intravenous" and parameterization set
to either "Clearance" ,"Micro" , or "Macro"
Models with absorption set to either "Gamma" ,
"InverseGaussian" , or "Weibull"
Aa Column mapping argument that represents the input dataset column
for the amount of drug administered and only applicable to models with absorption = "FirstOrder" .
A Column mapping argument that represents the input dataset column
for the amount of drug administered and only applicable to models with
absorption = "Intravenous" and parameterization = "Macro1" .
A1_Rate Column mapping argument that represents the input dataset column
for the rate of drug administered. Only applicable to the following types of models:
Models with absorption = "Intravenous" , infusionAllowed = TRUE
and parameterization set to either "Clearance" ,"Micro" or "Macro"
Models with absorption set to either "Gamma" , "InverseGaussian" ,
or "Weibull" and infusionAllowed = TRUE
A1_Duration Column mapping argument that represents the input dataset column
for the duration of drug administered. Only applicable to the following types of models:
Models with absorption = "Intravenous" ,infusionAllowed = TRUE
with isDuration = TRUE and parameterization set to either "Clearance" ,
"Micro" or "Macro"
Models with absorption set to either "Gamma" , "InverseGaussian" ,
or "Weibull" and infusionAllowed = TRUE with isDuration = TRUE
Aa_Rate Column mapping argument that represents the input dataset column
for the rate of drug administered and only applicable to models with absorption = "FirstOrder" ,
infusionAllowed = TRUE .
Aa_Duration Column mapping argument that represents the input dataset column
for the duration of drug administered and only applicable to models with absorption = "FirstOrder" ,
infusionAllowed = TRUE , and isDuration = TRUE .
A_Rate Column mapping argument that represents the input dataset column
for the rate of drug administered and only applicable to models with absorption = "Intravenous" ,
infusionAllowed = TRUE , and parameterization = "Macro1" .
A_Duration Column mapping argument that represents the input dataset column
for the duration of drug administered and only applicable to models with absorption = "Intravenous" ,
infusionAllowed = TRUE , isDuration = TRUE , and parameterization = "Macro1" .
A1Strip Column mapping argument that represents the input dataset column
for the stripping dose and only applicable to models with parameterization = "Macro" .
CObs Column mapping argument that represents the input dataset column
for the observations of drug concentration in the central compartment and only applicable
to models with parameterization being either set to either "Clearance" or "Micro" .
C1Obs Column mapping argument that represents the input dataset column
for the observations of drug concentration in the central compartment and only applicable
to models with parameterization being either set to either "Macro" or "Macro1" .
A0Obs Column mapping argument that represents the input dataset column
for the observed amount of drug in the elimination compartment. (hasEliminationComp = TRUE ).
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