enrollment |
Simulate enrollment times |
goldilocks |
goldilocks |
ppwe |
Cumulative distribution function of the PWE for a vectorized hazard rate parameter |
prop_to_haz |
Estimate plausible piecewise constant hazard rates from summary summary event proportions |
pwe_impute |
Impute piecewise exponential time-to-event outcomes |
pwe_sim |
Simulate piecewise exponential time-to-event outcomes |
randomization |
Randomization allocation |
sim_comp_data |
Simulate a complete clinical trial with event data drawn from a piecewise exponential distribution |
sim_trials |
Simulate one or more clinical trials subject to known design parameters and treatment effect |
summarise_sims |
Summarize simulations to get operating characteristics |
survival_adapt |
Simulate and execute a single adaptive clinical trial design with a time-to-event endpoint |