/*=========================================================================
 *
 *  Copyright UMC Utrecht and contributors
 *
 *  Licensed under the Apache License, Version 2.0 (the "License");
 *  you may not use this file except in compliance with the License.
 *  You may obtain a copy of the License at
 *
 *        http://www.apache.org/licenses/LICENSE-2.0.txt
 *
 *  Unless required by applicable law or agreed to in writing, software
 *  distributed under the License is distributed on an "AS IS" BASIS,
 *  WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 *  See the License for the specific language governing permissions and
 *  limitations under the License.
 *
 *=========================================================================*/
#ifndef _itkCombinationImageToImageMetric_hxx
#define _itkCombinationImageToImageMetric_hxx

#include "itkCombinationImageToImageMetric.h"
#include "itkTimeProbe.h"
#include "itkMath.h"

/** Macros to reduce some copy-paste work.
 * These macros provide the implementation of
 * all Set/GetFixedImage, Set/GetInterpolator etc methods
 *
 * The macros are undef'ed at the end of this file
 */

/** For setting objects, implement two methods */
#define itkImplementationSetObjectMacro2(_name, _type1, _type2)                                                     \
  template <typename TFixedImage, typename TMovingImage>                                                            \
  void CombinationImageToImageMetric<TFixedImage, TMovingImage>::Set##_name(_type1 _type2 * _arg, unsigned int pos) \
  {                                                                                                                 \
    if (pos == 0)                                                                                                   \
    {                                                                                                               \
      this->Superclass::Set##_name(_arg);                                                                           \
    }                                                                                                               \
    ImageMetricType *    testPtr1 = dynamic_cast<ImageMetricType *>(this->GetMetric(pos));                          \
    PointSetMetricType * testPtr2 = dynamic_cast<PointSetMetricType *>(this->GetMetric(pos));                       \
    if (testPtr1)                                                                                                   \
    {                                                                                                               \
      testPtr1->Set##_name(_arg);                                                                                   \
    }                                                                                                               \
    else if (testPtr2)                                                                                              \
    {                                                                                                               \
      testPtr2->Set##_name(_arg);                                                                                   \
    }                                                                                                               \
  }                                                                                                                 \
  template <typename TFixedImage, typename TMovingImage>                                                            \
  void CombinationImageToImageMetric<TFixedImage, TMovingImage>::Set##_name(_type1 _type2 * _arg)                   \
  {                                                                                                                 \
    for (unsigned int i = 0; i < this->GetNumberOfMetrics(); ++i)                                                   \
    {                                                                                                               \
      this->Set##_name(_arg, i);                                                                                    \
    }                                                                                                               \
  } // comments for allowing ; after calling the macro

#define itkImplementationSetObjectMacro1(_name, _type1, _type2)                                                     \
  template <typename TFixedImage, typename TMovingImage>                                                            \
  void CombinationImageToImageMetric<TFixedImage, TMovingImage>::Set##_name(_type1 _type2 * _arg, unsigned int pos) \
  {                                                                                                                 \
    if (pos == 0)                                                                                                   \
    {                                                                                                               \
      this->Superclass::Set##_name(_arg);                                                                           \
    }                                                                                                               \
    ImageMetricType * testPtr1 = dynamic_cast<ImageMetricType *>(this->GetMetric(pos));                             \
    if (testPtr1)                                                                                                   \
    {                                                                                                               \
      testPtr1->Set##_name(_arg);                                                                                   \
    }                                                                                                               \
  }                                                                                                                 \
  template <typename TFixedImage, typename TMovingImage>                                                            \
  void CombinationImageToImageMetric<TFixedImage, TMovingImage>::Set##_name(_type1 _type2 * _arg)                   \
  {                                                                                                                 \
    for (unsigned int i = 0; i < this->GetNumberOfMetrics(); ++i)                                                   \
    {                                                                                                               \
      this->Set##_name(_arg, i);                                                                                    \
    }                                                                                                               \
  } // comments for allowing ; after calling the macro

/** for getting const object, implement one method */
#define itkImplementationGetConstObjectMacro1(_name, _type)                                                        \
  template <typename TFixedImage, typename TMovingImage>                                                           \
  auto CombinationImageToImageMetric<TFixedImage, TMovingImage>::Get##_name(unsigned int pos) const->const _type * \
  {                                                                                                                \
    const ImageMetricType * testPtr1 = dynamic_cast<const ImageMetricType *>(this->GetMetric(pos));                \
    if (testPtr1)                                                                                                  \
    {                                                                                                              \
      return testPtr1->Get##_name();                                                                               \
    }                                                                                                              \
    else                                                                                                           \
    {                                                                                                              \
      return 0;                                                                                                    \
    }                                                                                                              \
  } // comments for allowing ; after calling the macro

#define itkImplementationGetConstObjectMacro2(_name, _type)                                                        \
  template <typename TFixedImage, typename TMovingImage>                                                           \
  auto CombinationImageToImageMetric<TFixedImage, TMovingImage>::Get##_name(unsigned int pos) const->const _type * \
  {                                                                                                                \
    const ImageMetricType *    testPtr1 = dynamic_cast<const ImageMetricType *>(this->GetMetric(pos));             \
    const PointSetMetricType * testPtr2 = dynamic_cast<const PointSetMetricType *>(this->GetMetric(pos));          \
    if (testPtr1)                                                                                                  \
    {                                                                                                              \
      return testPtr1->Get##_name();                                                                               \
    }                                                                                                              \
    else if (testPtr2)                                                                                             \
    {                                                                                                              \
      return testPtr2->Get##_name();                                                                               \
    }                                                                                                              \
    else                                                                                                           \
    {                                                                                                              \
      return 0;                                                                                                    \
    }                                                                                                              \
  } // comments for allowing ; after calling the macro

namespace itk
{

itkImplementationSetObjectMacro2(Transform, , TransformType);
itkImplementationSetObjectMacro1(Interpolator, , InterpolatorType);
itkImplementationSetObjectMacro2(FixedImageMask, const, FixedImageMaskType);
itkImplementationSetObjectMacro2(MovingImageMask, const, MovingImageMaskType);
itkImplementationSetObjectMacro1(FixedImage, const, FixedImageType);
itkImplementationSetObjectMacro1(MovingImage, const, MovingImageType);

itkImplementationGetConstObjectMacro2(Transform, TransformType);
itkImplementationGetConstObjectMacro1(Interpolator, InterpolatorType);
itkImplementationGetConstObjectMacro2(FixedImageMask, FixedImageMaskType);
itkImplementationGetConstObjectMacro2(MovingImageMask, MovingImageMaskType);
itkImplementationGetConstObjectMacro1(FixedImage, FixedImageType);
itkImplementationGetConstObjectMacro1(MovingImage, MovingImageType);


/**
 * ********************* Constructor ****************************
 */

template <typename TFixedImage, typename TMovingImage>
CombinationImageToImageMetric<TFixedImage, TMovingImage>::CombinationImageToImageMetric()
{
  this->ComputeGradientOff();

} // end Constructor


/**
 * ********************* PrintSelf ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::PrintSelf(std::ostream & os, Indent indent) const
{
  /** Call the superclass' PrintSelf. */
  Superclass::PrintSelf(os, indent);

  /** Add debugging information. */
  os << "NumberOfMetrics: " << this->m_NumberOfMetrics << std::endl;
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    os << "Metric " << i << ":\n";
    os << indent << "MetricPointer: " << this->m_Metrics[i].GetPointer() << "\n";
    os << indent << "MetricWeight: " << this->m_MetricWeights[i] << "\n";
    os << indent << "MetricRelativeWeight: " << this->m_MetricRelativeWeights[i] << "\n";
    os << indent << "UseRelativeWeights: " << (this->m_UseRelativeWeights ? "true\n" : "false\n");
    os << indent << "MetricValue: " << this->m_MetricValues[i] << "\n";
    os << indent << "MetricDerivativesMagnitude: " << this->m_MetricDerivativesMagnitude[i] << "\n";
    os << indent << "UseMetric: " << (this->m_UseMetric[i] ? "true\n" : "false\n");
    os << indent << "MetricComputationTime: " << this->m_MetricComputationTime[i] << "\n";
  }

} // end PrintSelf()


/**
 * ******************** SetFixedImageRegion ************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetFixedImageRegion(const FixedImageRegionType _arg,
                                                                              unsigned int               pos)
{
  if (pos == 0)
  {
    this->Superclass::SetFixedImageRegion(_arg);
  }
  auto * testPtr = dynamic_cast<ImageMetricType *>(this->GetMetric(pos));
  if (testPtr)
  {
    testPtr->SetFixedImageRegion(_arg);
  }

} // end SetFixedImageRegion()


/**
 * ******************** SetFixedImageRegion ************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetFixedImageRegion(const FixedImageRegionType _arg)
{
  for (unsigned int i = 0; i < this->GetNumberOfMetrics(); ++i)
  {
    this->SetFixedImageRegion(_arg, i);
  }

} // end SetFixedImageRegion()


/**
 * ******************** GetFixedImageRegion ************************
 */

template <typename TFixedImage, typename TMovingImage>
auto
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetFixedImageRegion(unsigned int pos) const
  -> const FixedImageRegionType &
{
  const auto * testPtr = dynamic_cast<const ImageMetricType *>(this->GetMetric(pos));
  if (testPtr)
  {
    return testPtr->GetFixedImageRegion();
  }
  else
  {
    return this->m_NullFixedImageRegion;
  }

} // end GetFixedImageRegion()


/**
 * ********************* SetNumberOfMetrics ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetNumberOfMetrics(unsigned int count)
{
  if (count != this->m_Metrics.size())
  {
    this->m_NumberOfMetrics = count;
    this->m_Metrics.resize(count);
    this->m_MetricWeights.resize(count);
    this->m_MetricRelativeWeights.resize(count);
    this->m_UseMetric.resize(count);
    this->m_MetricValues.resize(count);
    this->m_MetricDerivatives.resize(count);
    this->m_MetricDerivativesMagnitude.resize(count);
    this->m_MetricComputationTime.resize(count);
    this->Modified();
  }

} // end SetNumberOfMetrics()


/**
 * ********************* SetMetric ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetMetric(SingleValuedCostFunctionType * metric,
                                                                    unsigned int                   pos)
{
  if (pos >= this->GetNumberOfMetrics())
  {
    this->SetNumberOfMetrics(pos + 1);
  }

  if (metric != this->m_Metrics[pos])
  {
    this->m_Metrics[pos] = metric;
    this->Modified();
  }

} // end SetMetric()


/**
 * ********************* GetMetric ****************************
 */

template <typename TFixedImage, typename TMovingImage>
auto
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetric(unsigned int pos) const
  -> SingleValuedCostFunctionType *
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return nullptr;
  }
  else
  {
    return this->m_Metrics[pos];
  }

} // end GetMetric()


/**
 * ********************* SetMetricWeight ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetMetricWeight(double weight, unsigned int pos)
{
  if (pos >= this->GetNumberOfMetrics())
  {
    this->SetNumberOfMetrics(pos + 1);
  }

  if (weight != this->m_MetricWeights[pos])
  {
    this->m_MetricWeights[pos] = weight;
    this->Modified();
  }

} // end SetMetricWeight()


/**
 * ********************* GetMetricWeight ****************************
 */

template <typename TFixedImage, typename TMovingImage>
double
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetricWeight(unsigned int pos) const
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return 0.0;
  }
  else
  {
    return this->m_MetricWeights[pos];
  }

} // end GetMetricWeight()


/**
 * ********************* SetMetricRelativeWeight ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetMetricRelativeWeight(double weight, unsigned int pos)
{
  if (pos >= this->GetNumberOfMetrics())
  {
    this->SetNumberOfMetrics(pos + 1);
  }

  if (weight != this->m_MetricRelativeWeights[pos])
  {
    this->m_MetricRelativeWeights[pos] = weight;
    this->Modified();
  }

} // end SetMetricRelativeWeight()


/**
 * ********************* GetMetricRelativeWeight ****************************
 */

template <typename TFixedImage, typename TMovingImage>
double
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetricRelativeWeight(unsigned int pos) const
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return 0.0;
  }
  else
  {
    return this->m_MetricRelativeWeights[pos];
  }

} // end GetMetricRelativeWeight()


/**
 * ********************* SetUseMetric ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetUseMetric(const bool use, const unsigned int pos)
{
  if (pos >= this->GetNumberOfMetrics())
  {
    this->SetNumberOfMetrics(pos + 1);
  }

  if (use != this->m_UseMetric[pos])
  {
    this->m_UseMetric[pos] = use;
    this->Modified();
  }

} // end SetUseMetric()


/**
 * ********************* SetUseAllMetrics ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::SetUseAllMetrics()
{
  for (unsigned int pos = 0; pos < this->GetNumberOfMetrics(); ++pos)
  {
    if (!this->m_UseMetric[pos])
    {
      this->m_UseMetric[pos] = true;
      this->Modified();
    }
  }

} // end SetUseAllMetrics()


/**
 * ********************* GetUseMetric ****************************
 */

template <typename TFixedImage, typename TMovingImage>
bool
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetUseMetric(unsigned int pos) const
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return false;
  }
  else
  {
    return this->m_UseMetric[pos];
  }

} // end GetUseMetric()


/**
 * ********************* GetMetricValue ****************************
 */

template <typename TFixedImage, typename TMovingImage>
auto
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetricValue(unsigned int pos) const -> MeasureType
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return 0.0;
  }
  else
  {
    return this->m_MetricValues[pos];
  }

} // end GetMetricValue()


/**
 * ********************* GetMetricDerivative ****************************
 */

template <typename TFixedImage, typename TMovingImage>
auto
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetricDerivative(unsigned int pos) const
  -> const DerivativeType &
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return this->m_NullDerivative;
  }
  else
  {
    return this->m_MetricDerivatives[pos];
  }

} // end GetMetricDerivative()


/**
 * ********************* GetMetricDerivativeMagnitude ****************************
 */

template <typename TFixedImage, typename TMovingImage>
double
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetricDerivativeMagnitude(unsigned int pos) const
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return 0.0;
  }
  else
  {
    return this->m_MetricDerivativesMagnitude[pos];
  }

} // end GetMetricDerivativeMagnitude()


/**
 * ********************* GetMetricComputationTime ****************************
 */

template <typename TFixedImage, typename TMovingImage>
double
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMetricComputationTime(unsigned int pos) const
{
  if (pos >= this->GetNumberOfMetrics())
  {
    return 0;
  }
  else
  {
    return this->m_MetricComputationTime[pos];
  }

} // end GetMetricComputationTime()


/**
 * **************** GetNumberOfPixelsCounted ************************
 */

template <typename TFixedImage, typename TMovingImage>
const SizeValueType &
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetNumberOfPixelsCounted() const
{
  unsigned long sum = 0;
  for (unsigned int i = 0; i < this->GetNumberOfMetrics(); ++i)
  {
    const auto * testPtr = dynamic_cast<const ImageMetricType *>(this->GetMetric(i));
    if (testPtr)
    {
      sum += testPtr->GetNumberOfPixelsCounted();
    }
  }

  Superclass::m_NumberOfPixelsCounted = sum;
  return Superclass::m_NumberOfPixelsCounted;

} // end GetNumberOfPixelsCounted()


/**
 * ********************* Initialize ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::Initialize()
{
  /** Check if transform, interpolator have been set. Effectively this
   * method checks if the first sub metric is set up completely.
   * This implicitly means that the first sub metric is an ImageToImageMetric,
   * which is a reasonable demand.
   */
  this->Superclass::Initialize();

  /** Check if at least one (image)metric is provided */
  if (this->GetNumberOfMetrics() == 0)
  {
    itkExceptionMacro("At least one metric should be set!");
  }

  /** Call Initialize for all metrics. */
  for (unsigned int i = 0; i < this->GetNumberOfMetrics(); ++i)
  {
    SingleValuedCostFunctionType * costfunc = this->GetMetric(i);
    if (!costfunc)
    {
      itkExceptionMacro("Metric " << i << " has not been set!");
    }
    auto * testPtr1 = dynamic_cast<ImageMetricType *>(this->GetMetric(i));
    auto * testPtr2 = dynamic_cast<PointSetMetricType *>(this->GetMetric(i));
    if (testPtr1)
    {
      // The NumberOfThreadsPerMetric is changed after Initialize() so we save it before and then
      // set it on.
      unsigned nrOfThreadsPerMetric = this->GetNumberOfWorkUnits();
      testPtr1->Initialize();
      testPtr1->SetNumberOfWorkUnits(nrOfThreadsPerMetric);
    }
    else if (testPtr2)
    {
      testPtr2->Initialize();
    }
  }

} // end Initialize()


/**
 * ******************* InitializeThreadingParameters *******************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::InitializeThreadingParameters() const
{
  /** Initialize the derivatives. */
  for (ThreadIdType i = 0; i < this->GetNumberOfMetrics(); ++i)
  {
    this->m_MetricDerivatives[i].SetSize(this->GetNumberOfParameters());
  }
} // end InitializeThreadingParameters()


/**
 * ******************* GetFinalMetricWeight *******************
 */

template <typename TFixedImage, typename TMovingImage>
double
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetFinalMetricWeight(unsigned int pos) const
{
  double weight = 1.0;
  if (!this->m_UseRelativeWeights)
  {
    weight = this->m_MetricWeights[pos];
  }
  else
  {
    /** The relative weight of metric i is such that the
     * magnitude of the derivative of metric i is rescaled
     * to be a fraction of that of metric 0; the fraction is
     * defined by the fraction of the two relative weights.
     * Note that this weight is different in each iteration.
     */
    if (this->m_MetricDerivativesMagnitude[pos] > 1e-10)
    {
      weight = this->m_MetricRelativeWeights[pos] * this->m_MetricDerivativesMagnitude[0] /
               this->m_MetricDerivativesMagnitude[pos];
    }
  }

  return weight;
} // end GetFinalMetricWeight()


/**
 * ********************* GetValue ****************************
 */

template <typename TFixedImage, typename TMovingImage>
auto
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetValue(const ParametersType & parameters) const
  -> MeasureType
{
  /** Initialise. */
  MeasureType measure{};

  /** Compute, store and combine all metric values. */
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    /** Time the computation per metric. */
    itk::TimeProbe timer;
    timer.Start();

    /** Compute ... */
    MeasureType tmpValue = this->m_Metrics[i]->GetValue(parameters);
    timer.Stop();

    /** store ... */
    this->m_MetricValues[i] = tmpValue;
    this->m_MetricComputationTime[i] = timer.GetMean() * 1000.0;

    /** and combine. */
    if (this->m_UseMetric[i])
    {
      if (!this->m_UseRelativeWeights)
      {
        measure += this->m_MetricWeights[i] * this->m_MetricValues[i];
      }
      else
      {
        /** The relative weight of metric i is such that the
         * value of metric i is rescaled
         * to be a fraction of that of metric 0; the fraction is
         * defined by the fraction of the two relative weights.
         * Note that this weight is different in each iteration.
         */
        double weight = 1.0;
        if (this->m_MetricValues[i] > 1e-10)
        {
          weight = this->m_MetricRelativeWeights[i] * this->m_MetricValues[0] / this->m_MetricValues[i];
          measure += weight * this->m_MetricValues[i];
        }
      }
    }
  }

  /** Return a value. */
  return measure;

} // end GetValue()


/**
 * ********************* GetDerivative ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetDerivative(const ParametersType & parameters,
                                                                        DerivativeType &       derivative) const
{
  /** Initialise. */
  DerivativeType tmpDerivative(this->GetNumberOfParameters());
  derivative.set_size(this->GetNumberOfParameters());
  derivative.Fill(MeasureType{});

  /** Compute, store and combine all metric derivatives. */
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    /** Time the computation per metric. */
    itk::TimeProbe timer;
    timer.Start();

    /** Compute ... */
    tmpDerivative.Fill(MeasureType{});
    this->m_Metrics[i]->GetDerivative(parameters, tmpDerivative);
    timer.Stop();

    /** store ... */
    this->m_MetricDerivatives[i] = tmpDerivative;
    this->m_MetricDerivativesMagnitude[i] = tmpDerivative.magnitude();
    this->m_MetricComputationTime[i] = timer.GetMean() * 1000.0;

    /** and combine. */
    if (this->m_UseMetric[i])
    {
      if (!this->m_UseRelativeWeights)
      {
        derivative += this->m_MetricWeights[i] * this->m_MetricDerivatives[i];
      }
      else
      {
        /** The relative weight of metric i is such that the
         * magnitude of the derivative of metric i is rescaled
         * to be a fraction of that of metric 0; the fraction is
         * defined by the fraction of the two relative weights.
         * Note that this weight is different in each iteration.
         */
        double weight = 1.0;
        if (this->m_MetricDerivativesMagnitude[i] > 1e-10)
        {
          weight = this->m_MetricRelativeWeights[i] * this->m_MetricDerivativesMagnitude[0] /
                   this->m_MetricDerivativesMagnitude[i];
          derivative += weight * this->m_MetricDerivatives[i];
        }
      }
    }
  }

} // end GetDerivative()


/**
 * ********************* GetValueAndDerivative ****************************
 */

template <typename TFixedImage, typename TMovingImage>
void
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetValueAndDerivative(const ParametersType & parameters,
                                                                                MeasureType &          value,
                                                                                DerivativeType &       derivative) const
{
  /** Declare timer. */
  itk::TimeProbe timer;

  /** This function must be called before the multi-threaded code.
   * It calls all the non thread-safe stuff.
   */
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    auto * testPtr1 = dynamic_cast<ImageMetricType *>(this->GetMetric(i));
    auto * testPtr2 = dynamic_cast<PointSetMetricType *>(this->GetMetric(i));
    if (testPtr1)
    {
      testPtr1->SetUseMetricSingleThreaded(true);
      testPtr1->BeforeThreadedGetValueAndDerivative(parameters);
      testPtr1->SetUseMetricSingleThreaded(false);
    }
    if (testPtr2)
    {
      testPtr2->SetUseMetricSingleThreaded(true);
      testPtr2->BeforeThreadedGetValueAndDerivative(parameters);
      testPtr2->SetUseMetricSingleThreaded(false);
    }
  }

  /** Initialize some threading related parameters. */
  this->InitializeThreadingParameters();

  /** Compute all metric values and derivatives. */
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    /** Compute ... */
    timer.Reset();
    timer.Start();
    this->m_Metrics[i]->GetValueAndDerivative(parameters, this->m_MetricValues[i], this->m_MetricDerivatives[i]);
    timer.Stop();

    /** Store computation time. */
    this->m_MetricComputationTime[i] = timer.GetMean() * 1000.0;
  }

  /** Compute the derivative magnitude. */
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    this->m_MetricDerivativesMagnitude[i] = this->m_MetricDerivatives[i].magnitude();
  }

  /** Combine the metric values. */
  value = MeasureType{};
  for (unsigned int i = 0; i < this->m_NumberOfMetrics; ++i)
  {
    if (this->m_UseMetric[i])
    {
      const double weight = this->GetFinalMetricWeight(i);
      value += weight * this->m_MetricValues[i];
    }
  }

  /** Combine the metric derivatives. First, the first derivative. */
  if (this->m_UseMetric[0])
  {
    const double weight = this->GetFinalMetricWeight(0);
    derivative = weight * this->m_MetricDerivatives[0];
  }
  else
  {
    derivative.Fill(0);
  }

  /** Then the remaining derivatives. */
  for (unsigned int i = 1; i < this->m_NumberOfMetrics; ++i)
  {
    if (this->m_UseMetric[i])
    {
      const double weight = this->GetFinalMetricWeight(i);
      derivative += weight * this->m_MetricDerivatives[i];
    }
  }

} // end GetValueAndDerivative()


/**
 * ********************* GetMTime ****************************
 */

template <typename TFixedImage, typename TMovingImage>
ModifiedTimeType
CombinationImageToImageMetric<TFixedImage, TMovingImage>::GetMTime() const
{
  ModifiedTimeType mtime = this->Superclass::GetMTime();
  ModifiedTimeType m;

  // Some of the following should be removed once this 'ivars' are put in the
  // input and output lists

  /** Check the modified time of the sub metrics */
  for (unsigned int i = 0; i < this->GetNumberOfMetrics(); ++i)
  {
    SingleValuedCostFunctionPointer metric = this->GetMetric(i);
    if (metric.IsNotNull())
    {
      m = metric->GetMTime();
      mtime = (m > mtime ? m : mtime);
    }
  }

  return mtime;

} // end GetMTime()


} // end namespace itk

#undef itkImplementationSetObjectMacro1
#undef itkImplementationSetObjectMacro2
#undef itkImplementationGetConstObjectMacro1
#undef itkImplementationGetConstObjectMacro2

#endif // end #ifndef _itkCombinationImageToImageMetric_hxx
